Used by itself and under strict dosage restrictions, there is little risk of physical harm with this drug. Combination with other drugs that affect the cardiovascular system (poppers, boner pills) and use alongside activities that decrease potassium stores (such as daily douching and deep douching) could cause fatal heart arrythmias.
The FDA indicates that this drug should not be used with amiodarone (Nexterone, Pacerone), chlorpromazine, haloperidol (Haldol), methadone (Dolophine, Methadose), moxifloxacin (Avelox), pentamidine (Nebupent, Pentam), procainamide, quinidine (in Nuedexta), sotalol (Betapace, Betapace AF), thioridazine, and ziprasidone (Geodon).
Loperamide stops movement of gas through tbe intestine, which may cause bloating and discomfort and can mask signs of perforation or injury. Absence of gas is an early indication of perforation or injury (when loperamide is not in use).